The concept of pesticide-likeness has been established in previous studies in terms of molecular properties ranges including molecular weight, calculated logP, the number of H-bond donors and acceptors, the number of aromatic bonds (considered to be correlated with pesticide photostability) and the number of rotatable bonds (related to bioavailability) [1]. Calculated molecular properties were used to predict oral drug-likeness in the field of drug discovery. So far the concept of pesticide-likeness did not yield same interest in comparison to the drug-likeness. Compared to drugs, pesticides are expected to have different absorption, distribution, metabolism, excretion and toxicity properties. In this study drug-likeness and pesticide-likeness concepts were compared and discussed for a set of 1741 commercial pesticides and a series of previously published 902 marketed drugs [2]. Their physicochemical property distributions were comparatively analyzed and the chemical space covered by drugs and pesticides was described using principal component analysis. Trends in constitutive properties of pesticides are discussed. Download poster